Journal article
In vitro response to functionalized self-assembled peptide scaffolds for three-dimensional cell culture
VN Modepalli, AL Rodriguez, R Li, S Pavuluri, KR Nicholas, CJ Barrow, DR Nisbet, RJ Williams
Biopolymers Peptide Science Section | WILEY-BLACKWELL | Published : 2014
DOI: 10.1002/bip.22469
Abstract
Nanomaterials are rich in potential, particularly for the formation of scaffolds that mimic the landscape of the host environment of the cell. This niche arises from the spatial organization of a series of biochemical and biomechanical signals. Self-assembling peptides have emerged as an important tool in the development of functional (bio-)nanomaterials; these simple, easily synthesized subunits form structures which present the properties of these larger, more complex systems. Scaffolds based upon these nanofibrous matrices are promising materials for regenerative medicine as part of a new methodology in scaffold design where a "bottom-up" approach is used in order to simulate the native c..
View full abstractGrants
Awarded by Australian Research Council Discovery Project Scheme
Awarded by NHMRC Career Development Fellowship
Funding Acknowledgements
[ "Contract grant sponsor: Australian Research Council Discovery Project Scheme", "Contract grant number: DP130103131", "Contract grant sponsor: Alfred Deakin Research Fellowship Scheme", "Contract grant sponsor: Australian Postgraduate Award (to ALR)", "Contract grant sponsor: Australian Research Council Australian Postdoctoral Fellowship (APD; to DRN)", "Contract grant sponsor: NHMRC Career Development Fellowship", "Contract grant number: APP1050684", "Contract grant sponsor: Alfred Deakin Research Fellowship (to RJW)", "Contract grant sponsor: Australian Microscopy and Microanalysis Research Facility (AMMRF); access to the facilities of the Centre for Advanced Microscopy (CAM)" ]